Klf4^tm1Khk
Targeted Allele Detail

Summary

• Symbol: Klf4^tm1Khk
• Name: Kruppel-like transcription factor 4 (gut); targeted mutation 1, Klaus H Kaestner
• MGI ID: MGI:2183917
• Synonyms: Klf4^fl, Klf4^loxP
• Gene: Klf4 Location: Chr4:55527143-55532466 bp, - strand Genetic Position: Chr4, 29.76 cM
• Alliance: Klf4^tm1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76493
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Single loxP sites were left flanking exons 2 and 3 after homologous recombination of a targeting vector and the subsequent removal of a floxed neo cassette. Deletion of the floxed region will result in a frameshift mutation at exon 4. (J:76493)

Expression

In Mice Carrying this Mutation:	48 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klf4 Mutation: 24 strains or lines available

References

• Original: J:76493 Katz JP, et al., The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002 Jun;129(11):2619-28
• All: 101 reference(s)