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Targeted Allele Detail
Symbol: Nrp2tm1.2Mom
Name: neuropilin 2; targeted mutation 1.2, Peter Mombaerts
MGI ID: MGI:2183904
Synonyms: Neuropilin-2-Delta, NP2-delta, Nrp2del, Nrp2taugfp, Nrp2tm1Mom
Gene: Nrp2  Location: Chr1:62703285-62818695 bp, + strand  Genetic Position: Chr1, 31.35 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:76686
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site 272 bp upstream of the translation initiation codon was introduced into exon 1 and a loxP-tauGFP FRT-flanked neo cassette was inserted 1 kb into intron 1 via homologous recombination. Heterozygous animals were crossed to an flp recombinase transgenic line for removal of the neo cassette. Subsequent mating to a cre recombinase transgenic line removed exon 1 and part of intron 1 leaving the tauGFP cassette intact. The exon 1 deletion removes the plasma membrane-targeting signal sequence and also brings the tauGFP cassette under the control of the endogenous promoter. RT-PCR analysis confirmed the removal of the signal sequence in gene transcripts from homozygous mutant animals. Immunohistochemistry of brain sections from homozygous mutants did not detect protein product. (J:76686)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrp2 Mutation:  55 strains or lines available
Original:  J:76686 Walz A, et al., Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice. J Neurosci. 2002 May 15;22(10):4025-35
All:  11 reference(s)

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MGI 6.11
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