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Eif2ak3tm1Drc
Targeted Allele Detail
Nomenclature
Symbol: Eif2ak3tm1Drc
Name: eukaryotic translation initiation factor 2 alpha kinase 3; targeted mutation 1, Douglas R Cavener
MGI ID: MGI:2183829
Synonyms: Perk-
Gene: Eif2ak3  Location: Chr6:70844515-70905245 bp, + strand  Genetic Position: Chr6, 32.09 cM
Acinar cells are lost in both Eif2ak3tm1Drc/Eif2ak3tm1Drc and Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc Tg(Ela1-cre)16Eps/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76661
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eif2ak3 Mutation:  9 strains or lines available
References
Original:  J:76661 Zhang P, et al., The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002 Jun;22(11):3864-74
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory