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Transgene Detail
Symbol: Tg(APOB)11Rub
Name: transgene insertion 11, Edward M Rubin
MGI ID: MGI:2183814
Synonyms: HuBTg
Transgene: Tg(APOB)11Rub  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(APOB)11Rub expresses 1 gene
Mutation detailsThe human APOB gene (~19 kb of genomic sequence 5' to the translational start site of the gene and ~14kb of genomic sequence 3' to the transcription termination site) was introduced into fertilized FVB mouse embryos. Multiple lines were generated, ranging in copy number from 1 to 11 for the human gene, by Southern blot. This transgene is the high-expressing line, with an estimated eleven copies of the APOB gene in liver of these mice. (J:78212)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:78212 Callow MJ, et al., Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2130-4
All:  17 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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