Ncoa2^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Ncoa2^tm1Ipc
• Name: nuclear receptor coactivator 2; targeted mutation 1, I Pierre Chambon
• MGI ID: MGI:2183797
• Synonyms: TIF2^L3
• Gene: Ncoa2 Location: Chr1:13209329-13444307 bp, - strand Genetic Position: Chr1, 4.12 cM, cytoband A3-A5
• Alliance: Ncoa2^tm1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78075
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The exon encoding the nuclear receptor interaction domain was flanked by an upstream loxP site and a downstream floxed neo cassette. Ncoa2^tm1.1Ipc and Ncoa2^tm1.2Ipc were generated by breeding mice carrying this allele with transgenic mice expressing cre recombinase via the CMV promoter. (J:78075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa2 Mutation: 78 strains or lines available

References

• Original: J:78075 Gehin M, et al., The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol. 2002 Aug;22(16):5923-37
• All: 1 reference(s)