Kif3c^tm3Gsn
Targeted Allele Detail

Summary

• Symbol: Kif3c^tm3Gsn
• Name: kinesin family member 3C; targeted mutation 3, Lawrence S B Goldstein
• MGI ID: MGI:2183789
• Synonyms: Kif3c^null
• Gene: Kif3c Location: Chr12:3415132-3456494 bp, + strand Genetic Position: Chr12, 1.77 cM
• Alliance: Kif3c^tm3Gsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70607
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.5 kb region of the gene including exon 1, which encode amino acids 1-518 including the whole motor region and half of the alpha-helical coiled coil domains, was replaced with a PGK-neo cassette via homologous recombination. Western blot analyis of brain lysates using antibodies directed against the C-terminus of the protein confirmed the absence of gene expression in homozygous mutant animals. (J:70607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kif3c Mutation: 24 strains or lines available

References

• Original: J:70607 Yang Z, et al., Functional analysis of mouse kinesin motor kif3c. Mol Cell Biol. 2001 Aug;21(16):5306-11
• All: 3 reference(s)