Tg(PMP22)C1Clh
Transgene Detail

Summary

• Symbol: Tg(PMP22)C1Clh
• Name: transgene insertion C1, Clare Huxley
• MGI ID: MGI:2183769
• Synonyms: C1
• Transgene: Tg(PMP22)C1Clh Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Tg(PMP22)C1Clh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PMP22)C1Clh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PMP22 (5376)

  Pmp22

  (MGI:97631)

• Mutation details: A YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was intact (including the region containing PMP22) except for the marker representing the right arm of the YAC. Founder C1 carries 2 copies of the human transgene on chromosome 7 with an expression level half that of the endogenous mouse gene. (J:77330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Heterozygous animals show no phenotype but homozygous transgenic animals exhibit weakness and progressive paralysis of the hind limbs.

References

• Original: J:77330 Huxley C, et al., Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice. Hum Mol Genet. 1998 Mar;7(3):449-58
• All: 2 reference(s)