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Tg(Pmp22)247Ueli
Transgene Detail
Nomenclature
Symbol: Tg(Pmp22)247Ueli
Name: transgene insertion 247, Ueli Suter
MGI ID: MGI:2183755
Synonyms: TgN247, TgN(pmp22Ge)247Zbz
Transgene: Tg(Pmp22)247Ueli  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Founder 247 is representative of 2 founders (247 and 249) carrying approximately 30 copies of the transgene and exhibiting similar phenotypes. Transgenic animals display slight shivering at 2 weeks of age most apparent in the head. At 4 weeks the animals exhibit unsteady gait and progress to muscle atrophy at 2-3 months leading eventually to hind limb paralysis.

References
Original:  J:34938 Magyar JP, et al., Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage. J Neurosci. 1996 Sep 1;16(17):5351-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory