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Crabp2tm1Ipc
Targeted Allele Detail
Nomenclature
Symbol: Crabp2tm1Ipc
Name: cellular retinoic acid binding protein II; targeted mutation 1, Pierre Chambon
MGI ID: MGI:2183745
Synonyms: CRABPII -
Gene: Crabp2  Location: Chr3:87948693-87953372 bp, + strand  Genetic Position: Chr3, 38.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23139
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequences in exon 1 between nucleotides +119 and +164 were replaced with a neomycin selection cassette. The deleted sequences include the translation initiation site and the first 5 codons. RNase protection assays on E13.5 embryos demonstrated that an abnormal transcript was expressed from this allele, but no signal was detected in western blots in extracts derived from E13.5 homozygous embryos. (J:23139)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crabp2 Mutation:  19 strains or lines available
References
Original:  J:23139 Lampron C, et al., Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal. Development. 1995 Feb;121(2):539-48
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory