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Tg(Sod1*G86R)M1Jwg
Transgene Detail
Nomenclature
Symbol: Tg(Sod1*G86R)M1Jwg
Name: transgene insertion M1, Jon W Gordon
MGI ID: MGI:2183736
Synonyms: M1, Tg(Sod1*G85R)M1Jwg, Tg(Sod1-G86R)M1Jwg
Transgene: Tg(Sod1*G86R)M1Jwg  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Sod1*G86R)M1Jwg expresses 1 gene
 
Mutation detailsThe entire mouse Sod1 gene with an engineered point mutation in exon 4 resulting in a glycine to arginine substitution at residue 86 (G86R) was used as the transgene. Mutation G86R corresponds to the SOD1 G86R mutation found in some cases of human amyotrophic lateral sclerosis (ALS) patients. RT-PCR analysis detected expression of the transgene in brain, spinal cord, and other tissues. The missense mutation is a point mutation in exon 4 resulting in a glycine-86 to arginine substitution, which corresponds to amino acid position 86 in the human SOD1 protein. Transgenics exhibit widespread high expression of the transgene and do not exhibit diminished SOD1 activity. . (J:22628)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:22628 Ripps ME, et al., Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):689-93
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory