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Transgene Detail
Symbol: Tg(Sod1*G86R)M1Jwg
Name: transgene insertion M1, Jon W Gordon
MGI ID: MGI:2183736
Synonyms: M1, Tg(Sod1*G85R)M1Jwg, Tg(Sod1-G86R)M1Jwg
Transgene: Tg(Sod1*G86R)M1Jwg  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Sod1*G86R)M1Jwg expresses 1 gene
Mutation detailsThe entire mouse Sod1 gene with an engineered point mutation in exon 4 resulting in a glycine to arginine substitution at residue 86 (G86R) was used as the transgene. Mutation G86R corresponds to the SOD1 G86R mutation found in some cases of human amyotrophic lateral sclerosis (ALS) patients. RT-PCR analysis detected expression of the transgene in brain, spinal cord, and other tissues. The missense mutation is a point mutation in exon 4 resulting in a glycine-86 to arginine substitution, which corresponds to amino acid position 86 in the human SOD1 protein. Transgenics exhibit widespread high expression of the transgene and do not exhibit diminished SOD1 activity. . (J:22628)
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:22628 Ripps ME, et al., Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):689-93
All:  21 reference(s)

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