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Transgene Detail
Symbol: Tg(SOD1*G93A)1Gur
Name: transgene insertion 1, Mark E Gurney
MGI ID: MGI:2183719
Synonyms: G1H, G93A, G93A+, G93AGurdl, G93A SOD1, G93A-SOD1, (G93A)Tg+, hSOD1G93A, SOD1G93A, SOD1 G93A, SOD1 Tg, Tg(G93A-SOD1)1Gur, TgN(SOD1-G93A)1Gur, TgN[SOD1-G93A]1Gur, Tg(SOD1-G93A)1Gur
Transgene: Tg(SOD1*G93A)1Gur  Location: unknown  Genetic Position: Chr12, cytoband E
Presence of neurofilament spheroids in the spinal cord of an 82-day old Tg(SOD1)2Gur/0 mouse

Show the 5 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation details
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Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
This line, G1H, was derived from the original G1 line (now designated Tg(SOD1*G93A)2Gur) reported in J:32665.

Transgenic mice on a background that involves C57BL/6 and SJL express high levels of the transgene with a 4-fold increase in SOD activity, and exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans. Hemizygous transgenic mice become paralyzed in one or more limbs and have a life span of approximately 19-23 weeks. Paralysis is due to loss of motor neurons from the spinal cord.

Original:  J:76718 Tu PH, et al., Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3155-60
All:  413 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.20
The Jackson Laboratory