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Transgene Detail
Symbol: Tg(SOD1*G93A)2Gur
Name: transgene insertion 2, Mark E Gurney
MGI ID: MGI:2183718
Synonyms: G1, G1L, hMg-SOD1(G93A), Tg(SOD1)2Gur, Tg(SOD1-G93A)2Gur
Transgene: Tg(SOD1*G93A)2Gur  Location: unknown  Genetic Position: Chr12, Syntenic
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(SOD1*G93A)2Gur expresses 1 gene
Mutation detailsThe transgene construct consists of a human SOD1 gene carrying a glycine to alanine substitution at position 93 (G93A). The G93A mutation does not alter the activity of the protein. Northern blot and Western blot confirmed the expression of the human transgene in transgenic animals. (J:32665, J:43332, J:43347)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available

This is the original high copy number line, G1, reported in J:32556. Subsequently, the Tg(SOD1*G93A)1Gur line, which has a 40% greater copy number was derived from the original founder G1 and reported in J:76718.

Original:  J:32665 Gurney ME, et al., Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]. Science. 1994 Jun 17;264(5166):1772-5
All:  49 reference(s)

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