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Rxrgtm2Ysa
Targeted Allele Detail
Nomenclature
Symbol: Rxrgtm2Ysa
Name: retinoid X receptor gamma; targeted mutation 2, Yumiko Saga
MGI ID: MGI:2183717
Synonyms: TV-2
Gene: Rxrg  Location: Chr1:167598384-167639623 bp, + strand  Genetic Position: Chr1, 74.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77613
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into the isoform-specific exon 2. By targeting exon 2, transcription of the isoform most prominent in brain tissue is ablated, while the isoform which is produced from a transcript in which exon 1b splices to exon 3, and is most abundant in skeletal muscle, is unaffected. (J:77613)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxrg Mutation:  9 strains or lines available
References
Original:  J:77613 Saga Y, et al., Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoform. Genes Cells. 1999 Apr;4(4):219-28
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory