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Targeted Allele Detail
Symbol: Itgb4tm1Efu
Name: integrin beta 4; targeted mutation 1, Elaine Fuchs
MGI ID: MGI:2183630
Synonyms: beta4-
Gene: Itgb4  Location: Chr11:115974725-116008412 bp, + strand  Genetic Position: Chr11, 80.91 cM
Separation at the mesenchymal-epithelial junctions in skin of Itgb4tm1Efu/Itgb4tm1Efu mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77644
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin selection cassette deleted sequence extending from 115 base pairs downstream of the start codon through intron 3. The absence of normal transcript in homozygous mutant mice was determined via RT-PCR analysis. While truncated transcript was detected, immunoblot analysis showed an absence of protein. (J:77644)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb4 Mutation:  5 strains or lines available
Original:  J:77644 Dowling J, et al., Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol. 1996 Jul;134(2):559-72
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory