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Mxd3tm1Rne
Targeted Allele Detail
Nomenclature
Symbol: Mxd3tm1Rne
Name: Max dimerization protein 3; targeted mutation 1, Robert N Eisenman
MGI ID: MGI:2183621
Synonyms: mad3-
Gene: Mxd3  Location: Chr13:55325168-55329823 bp, - strand  Genetic Position: Chr13, 29.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77649
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a region spanning the start codon in exon 1 and 5.8kb of intronic sequence following exon 4. In addtion to the initial methionine, the deleted sequence encoded the Sin3-interacting domain, a conserved HGYAS motif, and the basic and helix-loop-helix regions of the bHLH leucine zipper. RT-PCR analysis and in situ hybridization confirmed the absence of transcript in homozygous mutant embryos. (J:77649)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mxd3 Mutation:  1 strain or line available
References
Original:  J:77649 Queva C, et al., Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. Mol Cell Biol. 2001 Feb;21(3):703-12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory