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Mc4rtm1Dhu
Targeted Allele Detail
Nomenclature
Symbol: Mc4rtm1Dhu
Name: melanocortin 4 receptor; targeted mutation 1, Dennis Huszar
MGI ID: MGI:2183586
Synonyms: MC4r-, MC-4R(-), MC4r-KO
Gene: Mc4r  Location: Chr18:66857715-66860472 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38224
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced all but the first 20 nucleotides of the coding region. Northern blot analysis showed a lack of transcript in homozygous mice. (J:38224)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:  28 strains or lines available
References
Original:  J:38224 Huszar D, et al., Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997 Jan 10;88(1):131-41
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory