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Targeted Allele Detail
Symbol: Wt1tm1.1Jak
Name: Wilms tumor 1 homolog; targeted mutation 1.1 Jordan A Kreidberg
MGI ID: MGI:2183548
Synonyms: Wt1ex5c, Wt1ex5cre
Gene: Wt1  Location: Chr2:105126529-105173616 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:76780
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe neomycin cassette was removed from the Wt1tm1Jak allele via cre mediated recombination to create the Wttm1.1Jak allele. This resulted in the deletion of the mammalian specific alternatively spliced exon 5, which encodes a 17 amino acid sequence known to interact with the transcription factor Pawr. (J:76780)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:  21 strains or lines available
Original:  J:76780 Natoli TA, et al., A mammal-specific exon of WT1 is not required for development or fertility. Mol Cell Biol. 2002 Jun;22(12):4433-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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