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Frktm1Liu
Targeted Allele Detail
Nomenclature
Symbol: Frktm1Liu
Name: fyn-related kinase; targeted mutation 1, Edison T Liu
MGI ID: MGI:2183538
Synonyms: FRK-, frk/rak-
Gene: Frk  Location: Chr10:34483400-34611226 bp, + strand  Genetic Position: Chr10, 18.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77207
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1a and 1b were replaced with a neomycin selection cassette. The deleted region contained the 5' untranslated region, the start codon, and sequence encoding the amino terminal residues and the SH2 and SH3 domains. No transcript was detected by Northern blot anlysis of homozygous mutant mice. Western blot analysis confirmed the absence of protein. (J:77207)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Frk Mutation:  16 strains or lines available
References
Original:  J:77207 Chandrasekharan S, et al., Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Mol Cell Biol. 2002 Jul;22(14):5235-47
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory