Gjb2^tm1Ugds
Targeted Allele Detail

Summary

• Symbol: Gjb2^tm1Ugds
• Name: gap junction protein, beta 2; targeted mutation 1, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:2183509
• Synonyms: Cx26fl, Cx26^fl, Cx26^loxP, Gjb2^tm1Ptt
• Gene: Gjb2 Location: Chr14:57336059-57342159 bp, - strand Genetic Position: Chr14, 30.1 cM, cytoband D1-E1
• Alliance: Gjb2^tm1Ugds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77823
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The coding region in exon 2 was flanked by a loxP site in intron 1 and a floxed neo cassette inserted into exon 2. Immunohistofluorescence analysis showed that the expression pattern of this floxed allele did not differ from that of wild-type. (J:77823)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Gjb2 Mutation: 21 strains or lines available

References

• Original: J:77823 Cohen-Salmon M, et al., Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol. 2002 Jul 9;12(13):1106-11
• All: 41 reference(s)