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Targeted Allele Detail
Symbol: Mdm4tm1Glo
Name: transformed mouse 3T3 cell double minute 4; targeted mutation 1, Guillermina Lozano
MGI ID: MGI:2183485
Synonyms: Mdm4-
Gene: Mdm4  Location: Chr1:132959484-133030561 bp, - strand  Genetic Position: Chr1, 57.75 cM, cytoband G-G
Germline Transmission:  Earliest citation of germline transmission: J:71532
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 through 5 were replaced with a neomycin selection cassette. The deleted region encoded the majority of the Trp53-binding domain (amino acids 27-96). Aberrant splicing around the neo transgene would result in a frameshift mutation. Protein was undetected in homozygous mutant mice by Western blot analysis. (J:71532)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mdm4 Mutation:  181 strains or lines available
Original:  J:71532 Parant J, et al., Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet. 2001 Sep;29(1):92-5
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory