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Targeted Allele Detail
Symbol: Dad1tm1Wnt
Name: defender against cell death 1; targeted mutation 1, Astar Winoto
MGI ID: MGI:2183460
Synonyms: Ndelta26
Gene: Dad1  Location: Chr14:54235479-54254104 bp, - strand  Genetic Position: Chr14, 27.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:77676
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe Dad1 locus was disrupted by the insertion of a neomycin selection cassette that replaced exon 3 of Dad1 and the Tcra associated DNAse I hypersensitive sites 2 through 6. Neither Dad1 transcript nor protein was detected in homozygous mutant mice by RNAse protection or Western blot analyses. Expression analysis showed the deleted hypersensitive sites were necessary for the enhancement of Tcra transcription in a fraction of immature T cells. (J:77517, J:77676)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dad1 Mutation:  7 strains or lines available
Original:  J:77676 Hong NA, et al., A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Mol Cell Biol. 1997 Apr;17(4):2151-7
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory