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Targeted Allele Detail
Symbol: Ate1tm1Avar
Name: arginyltransferase 1; targeted mutation 1, Alexander Varshavsky
MGI ID: MGI:2183428
Synonyms: ATE1-, ATE1nlsLacZ
Gene: Ate1  Location: Chr7:129993223-130122099 bp, - strand  Genetic Position: Chr7, 73.19 cM
Small and lean phenotype of Ate1tm1Avar/Ate1tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77750
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 1-3 with a lacZ-PGK-neo derived cassette via homologous recombination. Absence of gene expression in homozygous mutant E13.5 embryos was demonstrated by Nothern blot analysis using a probe complementary to the deleted region. (J:77750)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 122 assay results
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ate1 Mutation:  29 strains or lines available
Original:  J:77750 Kwon YT, et al., An essential role of N-terminal arginylation in cardiovascular development. Science. 2002 Jul 5;297(5578):96-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory