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Vdrtm1.1Gcm
Targeted Allele Detail
Nomenclature
Symbol: Vdrtm1.1Gcm
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1.1, Geert Carmeliet
MGI ID: MGI:2183409
Synonyms: Leuven VDR-KO
Gene: Vdr  Location: Chr15:97854425-97910630 bp, - strand  Genetic Position: Chr15, 53.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72578
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe targeted mutation is a derivative of Vdrtm1Gcm. Exon 2 was deleted by crossing animals carrying Vdrtm1Gcm to a cre-expressing line. Absence of gene expression in homozygous mutant animals was demonstrated by RT-PCR analysis of duodenum, kidney, and bone tissue. (J:72578)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdr Mutation:  15 strains or lines available
References
Original:  J:72578 Van Cromphaut SJ, et al., Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13324-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory