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Targeted Allele Detail
Symbol: Runx3tm1Yg
Name: runt related transcription factor 3; targeted mutation 1, Yoram Groner
MGI ID: MGI:2183399
Synonyms: Runx3-
Gene: Runx3  Location: Chr4:135120652-135177990 bp, + strand  Genetic Position: Chr4, 67.19 cM
Pathological findings in large intestines of Runx3tm1Yg/Runx3tm1Yg and +/+ wild-type.

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77764
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsExon 2, encoding the runt domain, was disrupted by the insertion of a cassette containing IRES-lacZ and neo. RT-PCR analysis of dorsal root ganglia RNA extracts showed an absence of transcript in homozygous mutant mice. Protein was undetected by Western blot analysis of thymus tissue and immunostaining of dorsal root ganglia. Expression of beta-galactosidase was visualized in mutant embryos via X-gal staining. (J:77764)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 38 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx3 Mutation:  5 strains or lines available

Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease J:93240.

Phenotypic Similarity to Human Syndrome: Osteopenia, Congenital J:224290 in homozygotes.

Original:  J:77764 Levanon D, et al., The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002 Jul 1;21(13):3454-63
All:  16 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory