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Tpst1tm1Klm
Targeted Allele Detail
Nomenclature
Symbol: Tpst1tm1Klm
Name: protein-tyrosine sulfotransferase 1; targeted mutation 1, Kevin L Moore
MGI ID: MGI:2183366
Synonyms: Tpst-
Gene: Tpst1  Location: Chr5:130073326-130135729 bp, + strand  Genetic Position: Chr5, 68.53 cM, cytoband F-G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77674
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3, the first coding exon, was replaced with a neomycin selection cassette. A truncated transcript was detected in RNA derived from the testes and spleens of mutant mice. This transcript was undetected using a probe for exon 3, indicating that sequence encoding the 5' and 3' phosphate-binding domains was absent, thus translation would not result in a functional protein. (J:77674)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpst1 Mutation:  20 strains or lines available
References
Original:  J:77674 Ouyang YB, et al., Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. J Biol Chem. 2002 Jun 28;277(26):23781-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory