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Targeted Allele Detail
Symbol: Ktn1tm1.2Kpf
Name: kinectin 1; targeted mutation 1.2, Klaus Pfeffer
MGI ID: MGI:2183362
Synonyms: kntdelta/delta
Gene: Ktn1  Location: Chr14:47648448-47736564 bp, + strand  Genetic Position: Chr14, 24.6 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:77650
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated by breeding mice carrying Ktn1tm1Kpf with transgenic mice expressing cre recombinase in early development. Sequence intervening the floxed neomycin selection cassette inserted into intron 2 and the loxP site in intron 5 (exons 3 through 5) was excised. An aberrant transcript in which exon 2 splices to exon 6 and causes a frameshift mutation that introduces a stop codon was identified via RT-PCR and sequence analysis. Transcript was undetected by Northern blot analysis, putatively due to nonsense-mediated decay (NMD). Western blot analysis confirmed the absence of protein in homozygous mutant mice. (J:77650)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ktn1 Mutation:  46 strains or lines available
Original:  J:77650 Plitz T, et al., Intact lysosome transport and phagosome function despite kinectin deficiency. Mol Cell Biol. 2001 Sep;21(17):6044-55
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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