Cebpa^{tm1(Cebpb)Ylee}
Targeted Allele Detail

Summary

• Symbol: Cebpa^{tm1(Cebpb)Ylee}
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Ying-Hue Lee
• MGI ID: MGI:2183321
• Synonyms: C/ebp-alpha^beta
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^{tm1(Cebpb)Ylee} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77646
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cebpa^{tm1(Cebpb)Ylee} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cebpb (MGI:88373)

• Mutation details: A Cebpb knockin was generated by replacing the entire coding region of the Cebpa locus with the Cebpb coding region. A floxed neomycin selection cassette was inserted downstream of the stop codon. Homozygous mutant mice were bred with transgenic mice expressing cre recombinase, driven by the EIIa promoter, to generate mice carrying Cebpa^{tm1.1(Cebpb)Ylee}. (J:77646)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 18 strains or lines available

References

• Original: J:77646 Chen SS, et al., C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol. 2000 Oct;20(19):7292-9
• All: 1 reference(s)