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Tiam1tm1Jgc
Targeted Allele Detail
Nomenclature
Symbol: Tiam1tm1Jgc
Name: T cell lymphoma invasion and metastasis 1; targeted mutation 1, John G Collard
MGI ID: MGI:2183309
Synonyms: Tiam1-, Tiam KO
Gene: Tiam1  Location: Chr16:89787111-90143769 bp, - strand  Genetic Position: Chr16, 51.5 cM, cytoband C3-4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77148
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing both lacZ and neo genes was inserted in-frame in exon 2. Western blot analysis of homozygous mutant mice showed an absence of encoded protein in the cerebellum. Staining comparisons showed the expression of beta-galactosidase to be driven by the endogenous promoter. (J:77148)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tiam1 Mutation:  13 strains or lines available
References
Original:  J:77148 Malliri A, et al., Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature. 2002 Jun 20;417(6891):867-71
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory