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Targeted Allele Detail
Symbol: Clcn3tm1Tjj
Name: chloride channel, voltage-sensitive 3; targeted mutation 1, Thomas J Jentsch
MGI ID: MGI:2183297
Synonyms: ClC3-, Clcn3-
Gene: Clcn3  Location: Chr8:60910389-60983300 bp, - strand  Genetic Position: Chr8, 30.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:77635
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3, encoding the first transmembrane domain, and surrounding intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The absence of transcript in homozygous mutant mice was determined by an RNAse protection assay of brain RNA. Western blot analysis, using a specific antibody directed against the amino terminal region, indicated a lack of encoded protein. (J:77635)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn3 Mutation:  91 strains or lines available
Original:  J:77635 Stobrawa SM, et al., Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron. 2001 Jan;29(1):185-96
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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