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Zfpm1tm2Sho
Targeted Allele Detail
Nomenclature
Symbol: Zfpm1tm2Sho
Name: zinc finger protein, multitype 1; targeted mutation 2, Stuart Orkin
MGI ID: MGI:2183293
Gene: Zfpm1  Location: Chr8:122282141-122337251 bp, + strand  Genetic Position: Chr8, 70.86 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47281
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encoding the first 4 zinc finger domains was replaced with a floxed cassette containing a neomycin resistance gene and a cytosine deaminase gene, both under the control of PGK promoters. (J:47281)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfpm1 Mutation:  18 strains or lines available
References
Original:  J:47281 Tsang AP, et al., Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998 Apr 15;12(8):1176-88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory