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Targeted Allele Detail
Symbol: Cyp26a1tm1.1Ptk
Name: cytochrome P450, family 26, subfamily a, polypeptide 1; targeted mutation 1.1, Martin Petkovich
MGI ID: MGI:2183291
Synonyms: A1-, Cyp26a1-, L-
Gene: Cyp26a1  Location: Chr19:37697798-37701536 bp, + strand  Genetic Position: Chr19, 32.36 cM, cytoband C2-C3
Germline Transmission:  Earliest citation of germline transmission: J:67399
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis heritable allele is a derivative of Cyp26a1tm1Ptk in which the loxP flanked sequences, including exons 2-6 and the neomycin cassette, were deleted by breeding heterozygous mice to mice carrying cre recombinase. (J:67399)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 53 assay results
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp26a1 Mutation:  18 strains or lines available
Original:  J:67399 Abu-Abed S, et al., The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 2001 Jan 15;15(2):226-40
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory