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Targeted Allele Detail
Symbol: Ptentm1.1Mro
Name: phosphatase and tensin homolog; targeted mutation 1.1, Silvia Marino
MGI ID: MGI:2183285
Synonyms: Ptendel
Gene: Pten  Location: Chr19:32757577-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:77123
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsThis allele was generated by breeding mice carrying Ptentm1Mro with transgenic mice ubiquitously expressing cre recombinase. The expression of cre results in the excision of the floxed region containing exon 5. (J:77123)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  40 strains or lines available
Original:  J:77123 Marino S, et al., PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development. 2002 Jul;129(14):3513-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory