Stxbp1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Stxbp1^tm1Sud
• Name: syntaxin binding protein 1; targeted mutation 1, Thomas C Sudhoff
• MGI ID: MGI:2183278
• Synonyms: munc18-1^-
• Gene: Stxbp1 Location: Chr2:32677619-32737249 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Stxbp1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77237
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Five exons, encoding amino acids 14 through 144, were replaced with a neomycin selection cassette. Neither transcript nor protein was detected in homozygous mice by Northern blot or Western blot analyses. (J:77237)

Expression

In Mice Carrying this Mutation:	98 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stxbp1 Mutation: 47 strains or lines available

Notes

The targeting vector was electroporated into "G-cell" ES cells.

References

• Original: J:77237 Verhage M, et al., Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science. 2000 Feb 4;287(5454):864-9
• All: 32 reference(s)