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Targeted Allele Detail
Symbol: Diablotm1Mak
Name: diablo, IAP-binding mitochondrial protein; targeted mutation 1, Tak Mak
MGI ID: MGI:2183277
Synonyms: Smac-, SMAC-KO
Gene: Diablo  Location: Chr5:123509765-123525488 bp, - strand  Genetic Position: Chr5, 63.02 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:76248
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 2-4 with a PGK-neo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of mouse embryonic fibroblasts (MEFs) derived from E14.5 homozygous mutant embryos. No protein expression was detected. (J:76248)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Diablo Mutation:  8 strains or lines available
Original:  J:76248 Okada H, et al., Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol. 2002 May;22(10):3509-17
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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