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Targeted Allele Detail
Symbol: Clcn2tm1Mlv
Name: chloride channel, voltage-sensitive 2; targeted mutation 1, James E Melvin
MGI ID: MGI:2183262
Synonyms: ClC-2-, Clcn2-
Gene: Clcn2  Location: Chr16:20702964-20717746 bp, - strand  Genetic Position: Chr16, 12.5 cM
Retinal degeneration in Clcn2tm1Mlv/Clcn2tm1Mlv mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77673
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 1 and all of exon 2 were replaced with a neomycin selection cassette. Northern blot and Western blot analysis verified the absence of transcript and protein in homozygous mutant mice. (J:77673)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn2 Mutation:  14 strains or lines available
ES cell line = KG.
Original:  J:77673 Nehrke K, et al., Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem. 2002 Jun 28;277(26):23604-11
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory