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Targeted Allele Detail
Symbol: Clcn2tm1Tjj
Name: chloride channel, voltage-sensitive 2; targeted mutation 1, Thomas J Jentsch
MGI ID: MGI:2183261
Synonyms: Clcn2-
Gene: Clcn2  Location: Chr16:20702964-20717746 bp, - strand  Genetic Position: Chr16, 12.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:68137
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 3 and all of exons 4 through 7 were replaced with a neomycin selection cassette. The deleted region encoded transmembrane domains 2 through 6. Truncated transcript was detected by Northern blot analysis using 5' and neo probes and undetected using a 3' probe. Protein was shown to be absent in homozygous mutant mice via Western blot analysis. (J:68137)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn2 Mutation:  24 strains or lines available
Original:  J:68137 Bosl MR, et al., Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. EMBO J. 2001 Mar 15;20(6):1289-99
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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