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Tnfrsf11btm1Wss
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf11btm1Wss
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); targeted mutation 1, W Scott Simonet
MGI ID: MGI:2183229
Synonyms: OPG-
Gene: Tnfrsf11b  Location: Chr15:54250619-54278484 bp, - strand  Genetic Position: Chr15, 21.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47602
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette into exon 2 replaced sequence encoded the first 93 residues of the mature protein. This targeting strategy eliminated the first two cysteine-rich domains, which are essential for function, and introduced an in-frame stop codon. Northern blot analysis of total hepatic RNA confirmed the absence of transcript in homozygous mutant mice. (J:47602)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11b Mutation:  17 strains or lines available
References
Original:  J:47602 Bucay N, et al., osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998 May 1;12(9):1260-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory