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Targeted Allele Detail
Symbol: Ror2tm1Ymi
Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, Yasuhiro Minami
MGI ID: MGI:2183225
Synonyms: mRor2-, Ror2-
Gene: Ror2  Location: Chr13:53109317-53286124 bp, - strand  Genetic Position: Chr13, 27.68 cM, cytoband B3
Ror2Y324C/Ror2Y324C and Ror2tm1Ymi/Ror2tm1Ymi mice exhibit short tails at E10.75

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:60125
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons encoding an Ig-like domain with a neomycin resistance gene via homologous recombination. Western blot analysis confirmed the absence of protein expression in neural progenitor cells from homozygous mice. (J:60125, J:182150)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 43 assay results
In Structures Affected by this Mutation: 38 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ror2 Mutation:  104 strains or lines available
Original:  J:60125 Takeuchi S, et al., Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells. 2000 Jan;5(1):71-8
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory