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Gfaptm1Ito
Targeted Allele Detail
Nomenclature
Symbol: Gfaptm1Ito
Name: glial fibrillary acidic protein; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:2183216
Synonyms: Gfap-
Gene: Gfap  Location: Chr11:102887336-102897200 bp, - strand  Genetic Position: Chr11, 66.48 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22502
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette, containing a promoterless lacZ and neo, was inserted immediately downstream of the endogenous start codon. Western blot analysis of protein extracts obtained from cerebrum, cerebellum, and spinal cord tissue showed an absence of encoded protein in homozygous mutant mice. The expression pattern of beta-galactosidase showed a strong correlation to that of the endogenous gene. (J:22502)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gfap Mutation:  22 strains or lines available
References
Original:  J:22502 Gomi H, et al., Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Neuron. 1995 Jan;14(1):29-41
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory