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Dbptm2Schb
Targeted Allele Detail
Nomenclature
Symbol: Dbptm2Schb
Name: D site albumin promoter binding protein; targeted mutation 2, Ueli Schibler
MGI ID: MGI:2183205
Synonyms: Dbpdim, insertion KO
Gene: Dbp  Location: Chr7:45705088-45710203 bp, + strand  Genetic Position: Chr7, 29.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44434
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 4, which encodes the dimerization domain. Transcript produced from the targeted allele was detected via Northern blot analysis and RNA protection assay. Western blot analysis of nuclear extracts from homozygous mutant mice showed the absence of encoded protein. (J:44434)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dbp Mutation:  11 strains or lines available
References
Original:  J:44434 Lopez-Molina L, et al., The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J. 1997 Nov 17;16(22):6762-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory