Gabra1^tm1Uru
Targeted Allele Detail

Summary

• Symbol: Gabra1^tm1Uru
• Name: gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1, Uwe Rudolph
• MGI ID: MGI:2183154
• Synonyms: Gabra1^{Mutant Allele 1}
• Gene: Gabra1 Location: Chr11:42021766-42073757 bp, - strand Genetic Position: Chr11, 24.97 cM
• Alliance: Gabra1^tm1Uru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75895
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A point mutation was introduced into codon 101 (exon 4) resulting in the substitution of histidine with arginine (H101R). The targeting vector also contained a floxed neomycin cassette in intron 4 for selection. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Gabra1^tm1.1Uru. (J:75895)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra1 Mutation: 46 strains or lines available

References

• Original: J:75895 Rudolph U, et al., Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 1999 Oct 21;401(6755):796-800
• All: 2 reference(s)