Gabra1tm1Uru
Targeted Allele Detail
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Symbol: |
Gabra1tm1Uru |
Name: |
gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1, Uwe Rudolph |
MGI ID: |
MGI:2183154 |
Synonyms: |
Gabra1Mutant Allele 1 |
Gene: |
Gabra1 Location: Chr11:42021766-42073757 bp, - strand Genetic Position: Chr11, 24.97 cM
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Alliance: |
Gabra1tm1Uru page
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Germline Transmission: |
Earliest citation of germline transmission:
J:75895
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A point mutation was introduced into codon 101 (exon 4) resulting in the substitution of histidine with arginine (H101R). The targeting vector also contained a floxed neomycin cassette in intron 4 for selection. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Gabra1tm1.1Uru.
(J:75895)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gabra1 Mutation: |
47 strains or lines available
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Original: |
J:75895 Rudolph U, et al., Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 1999 Oct 21;401(6755):796-800 |
All: |
2 reference(s) |
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