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Gabra1tm1Uru
Targeted Allele Detail
Summary
Symbol: Gabra1tm1Uru
Name: gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1, Uwe Rudolph
MGI ID: MGI:2183154
Synonyms: Gabra1Mutant Allele 1
Gene: Gabra1  Location: Chr11:42021766-42073757 bp, - strand  Genetic Position: Chr11, 24.97 cM
Alliance: Gabra1tm1Uru page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75895
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA point mutation was introduced into codon 101 (exon 4) resulting in the substitution of histidine with arginine (H101R). The targeting vector also contained a floxed neomycin cassette in intron 4 for selection. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Gabra1tm1.1Uru. (J:75895)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:  47 strains or lines available
References
Original:  J:75895 Rudolph U, et al., Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 1999 Oct 21;401(6755):796-800
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory