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Tectatm1Gpr
Targeted Allele Detail
Nomenclature
Symbol: Tectatm1Gpr
Name: tectorin alpha; targeted mutation 1, Guy P Richardson
MGI ID: MGI:2183148
Synonyms: TectadeltaENT
Gene: Tecta  Location: Chr9:42329619-42399929 bp, - strand  Genetic Position: Chr9, 23.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77634
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insertion of a neomycin selection cassette disrupted exon 3. RT-PCR and sequence analysis of mutant mice revealed that the insertion of the neo cassette resulted in exon skipping, producing a transcript in which exons 2 and 4 are joined. While, encoded protein was undetected in homozygous mutant mice via Western blot analysis, immunofluorescence analysis showed immunoreactivity in the greater epithelial ridge and in isolated spots in the tectorial membrane. (J:77634)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tecta Mutation:  14 strains or lines available
References
Original:  J:77634 Legan PK, et al., A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron. 2000 Oct;28(1):273-85
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory