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Targeted Allele Detail
Symbol: Map2k4tm1Flv
Name: mitogen-activated protein kinase kinase 4; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2183040
Synonyms: MKK4 -
Gene: Map2k4  Location: Chr11:65688243-65788297 bp, - strand  Genetic Position: Chr11, 40.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:77628
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.5 kb fragment containg coding sequences for amino acids 211-268 was replaced with a neomycin selection cassette. These sequences include essential phosphorylation sites for protein activation. Western blot analysis on homozygous ES cells demonstrated that no detectable protein was made from this allele. (J:77628)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k4 Mutation:  22 strains or lines available
Original:  J:77628 Yang D, et al., Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3004-9
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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