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Il10rbtm1Agt
Targeted Allele Detail
Nomenclature
Symbol: Il10rbtm1Agt
Name: interleukin 10 receptor, beta; Targeted mutation 1, Michael Aguet
MGI ID: MGI:2182946
Synonyms: CRFB4-, IL-10-, IL-10R2-
Gene: Il10rb  Location: Chr16:91406164-91425834 bp, + strand  Genetic Position: Chr16, 52.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45917
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first two exons, encoding 39 amino acids including the signal peptide, were replaced with a neomycin cassette. Northern blot analysis of homozygous mutant ES cells showed an absence of transcript. (J:45917)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il10rb Mutation:  8 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:134156).
References
Original:  J:45917 Spencer SD, et al., The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med. 1998 Feb 16;187(4):571-8
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory