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Gcdhtm1Dmk
Targeted Allele Detail
Nomenclature
Symbol: Gcdhtm1Dmk
Name: glutaryl-Coenzyme A dehydrogenase; targeted mutation 1, David M Koeller
MGI ID: MGI:2182942
Synonyms: Gcdh-
Gene: Gcdh  Location: Chr8:84886393-84893921 bp, - strand  Genetic Position: Chr8, 41.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77874
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCoding sequences in exon 1 were fused in-frame to a lacZ gene followed by a neomycin resistance cassette, which also replaced the 3' end of exon 1 through exon 7. A beta-galactosidase protein was expressed from this allele under the control of the endogenous promoter. (J:77874)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcdh Mutation:  3 strains or lines available
References
Original:  J:77874 Koeller DM, et al., Biochemical, pathologic and behavioral analysis of a mouse model of glutaric acidemia type I. Hum Mol Genet. 2002 Feb 15;11(4):347-57
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory