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Targeted Allele Detail
Symbol: Cnr1tm1.1Ltz
Name: cannabinoid receptor 1 (brain); targeted mutation 1.1, Beat Lutz
MGI ID: MGI:2182924
Synonyms: CB1-, CB1null, CB1R-
Gene: Cnr1  Location: Chr4:33924593-33948831 bp, + strand  Genetic Position: Chr4, 16.28 cM
Germline Transmission:  Earliest citation of germline transmission: J:77936
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele was generated by breeding mice heterozygous for Cnr1tm1Ltz with transgenic mice ubiquitously expressing cre recombinase. Southern blot analysis showed that the entire open reading frame was removed, leaving a single loxP site and the FLP-recombinase target (FRT) flanked neo transgene in the single exon at this locus. A lack of transcript was determined via in situ hybridization of homozygous mutant embyros. (J:77936)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnr1 Mutation:  21 strains or lines available
Original:  J:77936 Marsicano G, et al., The endogenous cannabinoid system controls extinction of aversive memories. Nature. 2002 Aug 1;418(6897):530-4
All:  77 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory