Cnr1^tm1Ltz
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1Ltz
• Name: cannabinoid receptor 1; targeted mutation 1, Beat Lutz
• MGI ID: MGI:2182922
• Synonyms: CB1^floxed-neo
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1Ltz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77936
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The entire open reading frame was flanked by loxP sites and followed by a downstream FLP-recombinase target (FRT) flanked neo gene. Mice bearing this allele were bred with transgenic mice ubiquitously expressing cre to generate mice carrying Cnr1^tm1.1Ltz. (J:77936)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 43 strains or lines available

References

• Original: J:77936 Marsicano G, et al., The endogenous cannabinoid system controls extinction of aversive memories. Nature. 2002 Aug 1;418(6897):530-4
• All: 8 reference(s)