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Targeted Allele Detail
Symbol: Faahtm1Crv
Name: fatty acid amide hydrolase; targeted mutation 1, Benjamin F Cravatt
MGI ID: MGI:2182901
Synonyms: FAAH-
Gene: Faah  Location: Chr4:115967145-116017926 bp, - strand  Genetic Position: Chr4, 53.08 cM
Germline Transmission:  Earliest citation of germline transmission: J:70666
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 and approximately 2kb of upstream sequence were replaced by a PGK-neo selection cassette. Western blot analysis of brain and liver protein extracts and immunofluorescence analysis of cerebral sections showed an absence of encoded protein in homozygous mutant mice. Assays using labeled substrate showed significant reductions (50-100 fold) of hydrolytic activity in homozygous mutant mice. (J:70666)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Faah Mutation:  16 strains or lines available
Original:  J:70666 Cravatt BF, et al., Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9371-6
All:  57 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory