Evx1^tm1Gld
Targeted Allele Detail

Summary

• Symbol: Evx1^tm1Gld
• Name: even-skipped homeobox 1; targeted mutation 1, Martyn Goulding
• MGI ID: MGI:2182856
• Synonyms: Evx1^tau-myc, Evx1^tm
• Gene: Evx1 Location: Chr6:52290483-52295363 bp, + strand Genetic Position: Chr6, 25.44 cM
• Alliance: Evx1^tm1Gld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70192
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The portion of the homeodomain encoded by exon 3 was flanked by a loxP site in intron 2 and a cassette, containing a loxP site with an upstream neo gene and a downstream IRES-tau-myc, inserted into the 3' untranslated region. The targeting vector was designed such that the endogenous gene may be expressed prior to cre-mediated recombination. This allele was used to generate Evx1^tm1.1Gld. (J:70192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evx1 Mutation: 17 strains or lines available

References

• Original: J:70192 Moran-Rivard L, et al., Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron. 2001 Feb;29(2):385-99
• All: 1 reference(s)