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Tnfrsf21tm1Ddy
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf21tm1Ddy
Name: tumor necrosis factor receptor superfamily, member 21; targeted mutation 1, Derek D Yang
MGI ID: MGI:2182829
Synonyms: DR6-
Gene: Tnfrsf21  Location: Chr17:43016555-43089188 bp, + strand  Genetic Position: Chr17, 19.69 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70594
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3, which include the translation initiation site, were replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was demonstrated by Northern blot analysis of kidney RNA using a cDNA probe to exon 4. (J:70594)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf21 Mutation:  45 strains or lines available
References
Original:  J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory